![36. [gr]α-Reactivity and Condensation Reactions](https://is5-ssl.mzstatic.com/image/thumb/Podcasts/v4/d6/44/ae/d644aee3-10c5-ad52-fbe0-eff1858cb596/mza_2941438957742792652.jpg/600x600bb.jpg "36. [gr]α-Reactivity and Condensation Reactions")
36. [gr]α-Reactivity and Condensation Reactions
Update: 2012-04-02
Description
As in many synthetic procedures, an important challenge in ketone alkylation is choosing reagents and conditions that allow control of isomerism and of single vs. multiple substitution. [gr]β-Dicarbonyl compounds allow convenient alkylation and preparation of ketones and carboxylic acids. The aldol condensation, in which an [gr]a-position adds to a carbonyl group to generate a [gr]β-hydroxy- or an [gr]α,β-unsaturated carbonyl compound, can be driven to completion by removal of water. The Robinson annulation reaction is an important example of conjugate addition to [gr]α,β-unsaturated carbonyl compounds. [gr]α-Acylation of esters as in the Claisen condensation is a key step in the biosynthesis of fatty acids. Determining the constitutional structure of sugars posed a daunting challenge to early carbohydrate chemists.
Complete course materials are available at the Open Yale Courses website: http://oyc.yale.edu
This course was recorded in Spring 2011.
Complete course materials are available at the Open Yale Courses website: http://oyc.yale.edu
This course was recorded in Spring 2011.
Comments
In Channel
Download from Google Play
Download from App Store
United States00:00
00:00
x
